Pinky and the Brain first made their appearance on Steven Spielberg’s Animaniacs. The cartoon contained a slew of slap stick comedy and pop culture references, but the highlight of the show, for me anyway, was Pinky and the Brain. It was really no surprise when they finally got their own spin-off show in 1995. Who wouldn’t want to watch to genetically altered lab rats try and fail to take over the world every night?