Spider’s weapon of choice for most of the series is a handheld “bowel disruptor,” which causes instant and painful loss of bowel control, with various settings that allow him to vary the level of pain and discomfort the device will inflict, ranging from simple diarrhea to complete rectal prolapse. At a much harsher level, the victim has a bowel movement so dramatic and agonizing that it induces unconsciousness. While at least three times in the series, it is revealed through dialogue that the gun can be set to ‘Fatal Intestinal Maelstrom’. Spider prefers this weapon because, despite being illegal, it is (usually) non-lethal and its effects are untraceable. His assistants, Channon and Yelena, have also been armed with bowel disruptors during The Cure arc.
From Wikipedia
This is the bowel disruptor which is a weapon most often wielded by Spider Jerusalem in the comic Transmetropolitan by Warren Ellis. It is created to be life sized and is made entirely of yarn and stuffing. The dial on the sides even turns!